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Related Concept Videos

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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Related Experiment Video

Updated: Jan 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multiple Myeloma: A Continuously Evolving Disease.

Partha Mitra1

  • 1Hematology Clinical Trial, Flinders Cancer Innovation Centre, Bedford Park, South Australia.

Critical Reviews in Eukaryotic Gene Expression
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PubMed
Summary

Translational research bridges basic science discoveries with clinical applications. For multiple myeloma, this approach enhances diagnosis, prognosis, and patient survival through advanced technologies and evolving treatments.

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Area of Science:

  • Oncology
  • Translational Medicine
  • Clinical Research

Background:

  • Basic research generates knowledge applicable to clinical settings.
  • Translational research integrates benchtop findings into patient care.
  • Multiple myeloma is an incurable hematologic malignancy.

Purpose of the Study:

  • To illustrate how basic research and technology advance multiple myeloma care.
  • To highlight improvements in diagnosis, disease staging, and prognosis.
  • To demonstrate the impact of translational research on patient outcomes.

Main Methods:

  • Review of current translational research in multiple myeloma.
  • Application of cutting-edge technologies in diagnosis and prognosis.
  • Analysis of evolving treatment strategies.

Main Results:

  • Significant improvements in diagnosis and disease gradation.
  • Enhanced prognostic accuracy leading to better patient management.
  • Extended progression-free survival for multiple myeloma patients.

Conclusions:

  • Translational research is crucial for advancing oncology care.
  • Continuous evolution of treatments offers hope for incurable diseases like multiple myeloma.
  • Integration of basic science and technology significantly benefits patient survival and quality of life.