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Salidroside Combats Aging and Cancers through Oxidative Stress Mitigation.
1Chongqing Hospital of Traditional Chinese Medicine; 15736204002@163.com.
Journal of Visualized Experiments : Jove
|December 22, 2025
Summary
Salidroside, a compound from Rhodiola, shows promise in combating aging and pancreatic cancer. It works by reducing oxidative stress and modulating key cellular pathways for therapeutic benefits.
Area of Science:
- Pharmacology and Natural Product Chemistry
- Cellular Biology and Molecular Medicine
- Gerontology and Oncology
Background:
- Salidroside (Sal) is the main active compound in Rhodiola, utilized in traditional medicine and functional foods.
- Sal exhibits multi-target biological activities, making it a therapeutic candidate for aging and cancer, including pancreatic ductal adenocarcinoma.
- Its molecular structure, featuring glycosidic bonds and hydroxyl groups, underpins its antioxidant capacity and protein-binding potential.
Conclusions:
- Salidroside possesses significant antioxidant and multi-target properties beneficial for health.
- Its mechanisms involve the regulation of key signaling pathways, impacting both aging and cancer.
- Further research can facilitate the clinical translation of Salidroside for aging and cancer management.
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