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Peri-Prostatic Pacinian Corpuscles: A Multi-Institutional Series.

Laurence Aaron Galea1, Lisa Aviva Friedman2, Miruna Claudia Popescu3

  • 1Department of Anatomical Pathology, Melbourne Pathology, Sonic Healthcare, Victoria, Australia.

International Journal of Surgical Pathology
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

Pacinian corpuscles (PCs) are rarely found near the prostate. This study details 23 peri-prostatic PCs, investigating their features and identifying a novel clustered appearance suggesting PC hyperplasia.

Keywords:
Pacinian corpuscleselectron microscopyperi-prostaticprostate

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Area of Science:

  • Anatomical Pathology
  • Urology
  • Surgical Pathology

Background:

  • Pacinian corpuscles (PCs) are mechanoreceptors typically found in subcutaneous tissue.
  • Their presence in association with the prostate gland is considered an anatomical rarity.
  • Limited data exists on the morphology and significance of peri-prostatic PCs.

Purpose of the Study:

  • To report the largest series of peri-prostatic Pacinian corpuscles (PCs) to date.
  • To investigate the clinicopathological features of these structures.
  • To identify and characterize any unusual presentations, such as clustered appearances.

Main Methods:

  • Retrospective analysis of 23 peri-prostatic PCs from 14 patients undergoing radical prostatectomy or cystoprostatectomy.
  • Detailed examination of location, size, and shape.
  • Immunohistochemical and ultrastructural analysis of selected specimens.

Main Results:

  • 23 peri-prostatic PCs were identified in routine surgical pathology specimens.
  • Clinicopathological features including location, size, and morphology were documented.
  • A clustered appearance of PCs, termed PC hyperplasia, was observed in two patients for the first time.

Conclusions:

  • Pacinian corpuscles can be found in the peri-prostatic region, although infrequently.
  • Detailed investigation reveals consistent clinicopathological characteristics.
  • The novel finding of PC hyperplasia suggests a potential pathological response or condition in this location.