Related Experiment Video
Updated: Jan 8, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Clinicopathologic Correlation in a Case of Scurvy
Nathanael C Jensen1, Katherine Gillis2, Jamie Zussman1
1Department of Dermatology, University of Utah, Salt Lake City, UT.
Abstract:
Scurvy is an uncommon diagnosis in developed countries, yet it remains an important clinical consideration in patients with restrictive diets. In this study, we report a case of a male patient with a history of sclerosing mesenteritis and chronic dietary restriction who presented with bilateral leg purpura, perifollicular hemorrhage, and gingival bleeding. His cutaneous findings initially raised concern for vasculitis or coagulopathy. However, histopathology revealed classic features of scurvy and an undetectable vitamin C level confirmed the diagnosis. Oral vitamin C supplementation led to rapid clinical improvement. This case emphasizes the importance of a thorough dietary history and skin examination in patients presenting with mucocutaneous bleeding.
Related Concept Videos
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Endocarditis II: Clinical Features of Infective Endocarditis
Vitamins
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

