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Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
364
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

384
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
384
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

189
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
189
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

404
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
404
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

339
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
339
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

235
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
235

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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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Ventricular Septal Rupture Secondary to Late-Presenting Myocardial Infarction.

Joseph A Inger1, Jeffrey R Savarino2, Olivia Avidan3

  • 1Warren Alpert Medical School of Brown University, Providence, RI.

Rhode Island Medical Journal (2013)
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

Acute myocardial infarction (AMI) can cause serious mechanical complications like ventricular septal rupture (VSR). Early recognition and treatment are vital for improving patient outcomes and reducing high mortality rates associated with these rare but severe events.

Keywords:
Acute Myocardial InfarctionMechanical ComplicationVentricular Septal Rupture

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Area of Science:

  • Cardiology
  • Internal Medicine
  • Medical Case Reports

Background:

  • Over 800,000 acute myocardial infarction (AMI) events occur annually in the US.
  • While primary prevention and rapid intervention have decreased AMI incidence and complications, mechanical complications (MCs) still affect ~2,400 patients yearly.
  • MCs such as papillary muscle rupture, ventricular septal rupture (VSR), and free-wall rupture typically occur within 7 days of AMI and carry a >42% mortality rate.

Purpose of the Study:

  • To highlight the critical importance of recognizing and promptly treating post-AMI mechanical complications.
  • To present a case report illustrating a specific post-AMI mechanical complication: ventricular septal rupture (VSR).

Main Methods:

  • Review of clinical data and literature pertaining to post-AMI mechanical complications.
  • Detailed case report presentation of a patient experiencing VSR following AMI.

Main Results:

  • Mechanical complications, including VSR, remain a significant cause of mortality post-AMI, particularly in women and the elderly.
  • Prompt diagnosis and intervention are crucial for managing these life-threatening events.

Conclusions:

  • Post-AMI mechanical complications necessitate heightened awareness for timely diagnosis and management.
  • This case underscores the continued clinical relevance of understanding and addressing VSR and other MCs in AMI patients.