Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

8.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sinonasal and skull base phosphaturic mesenchymal tumours: a case series and narrative review.

Frontiers in endocrinology·2026
Same author

A Quantitative Modification of VI-RADS for Bladder Cancer at the Ureteral Orifice: A Reader Study on MRI With Varying Experience Levels.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Multi-Tissue Metabolomics Reveals Metabolic Signatures Associated with Lipid Partitioning Between Abdominal Fat and Egg Yolk in Laying Hens.

Animals : an open access journal from MDPI·2026
Same author

Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer.

Cell reports·2026
Same author

Prostate MRI Practices and PI-RADS Use in China's Mainland: A Nationwide Assessment and Opportunities for Standardization.

Journal of the American College of Radiology : JACR·2026
Same author

Floquet higher-order topological states induced by driving on-site potentials.

Optics express·2026

Related Experiment Video

Updated: Jan 8, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.7K

Robust Fat Suppression for High-Resolution DWI at 5 T Using Slice-Selection Gradient Modulation and Chemical Shift

Fan Liu1, Yiming Dong2, Wending Tang3

  • 1Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.

Magnetic Resonance in Medicine
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

A new two-step strategy combining slice-selection gradient modulation (SSGM) and Dixon effectively enhances fat suppression for 5 Tesla (5T) multi-shot EPI diffusion-weighted imaging (ms-EPI DWI). This advancement improves image quality for various anatomies and applications.

Keywords:
5 TDixondiffusion‐weighted imagingmulti‐shot EPIwater/fat separation

More Related Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

23.0K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.0K

Related Experiment Videos

Last Updated: Jan 8, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.7K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

23.0K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.0K

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Radiology

Background:

  • Chemical shift encoding (Dixon) effectively suppresses fat in multi-shot EPI diffusion-weighted imaging (ms-EPI DWI) at 3 Tesla (3T).
  • At 5 Tesla (5T), increased fat off-resonance frequencies cause slice position mismatches, rendering standard Dixon methods ineffective for simultaneous fat suppression.
  • Existing fat suppression techniques like SPAIR (Spectral Attenuated Inversion Recovery) show limitations at 5T for ms-EPI DWI.

Purpose of the Study:

  • To develop and evaluate a novel two-step strategy combining slice-selection gradient modulation (SSGM) and Dixon for enhanced fat suppression in 5T ms-EPI DWI.
  • To overcome the limitations of standard Dixon methods at 5T due to increased fat off-resonance frequencies.
  • To improve image quality and diagnostic potential of 5T ms-EPI DWI.

Main Methods:

  • A two-step strategy was implemented: 1) Slice-selection gradient modulation (SSGM) to excite but not refocus specific fat peaks (methyl/methylene).
  • 2) Dixon method with a joint water/fat separation algorithm using structured low-rank regularization to separate the remaining olefinic fat peak.
  • The method was evaluated in vivo across leg, head-and-neck, and prostate imaging.

Main Results:

  • The combined SSGM and Dixon strategy successfully achieved simultaneous fat suppression at 5T, unlike Dixon-only methods.
  • SSGM demonstrated superior methyl/methylene fat suppression compared to SPAIR, with subsequent Dixon removing residual olefinic fat.
  • Improved overall image quality was observed across all tested anatomies, including high-resolution (1.6-mm isotropic) and high b-value (2800 s/mm²) prostate imaging.

Conclusions:

  • The proposed two-step SSGM and Dixon strategy significantly enhances fat suppression in 5T ms-EPI DWI.
  • This improved fat suppression has the potential to advance whole-body disease screening and diagnosis using 5T MRI.
  • The method is applicable to various imaging scenarios, including reduced field-of-view acquisitions.