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SR-LLM: An incremental symbolic regression framework driven by LLM-based retrieval-augmented generation.

Zelin Guo1, Siqi Wang1, Yonglin Tian2

  • 1Department of Automation, Tsinghua University, Beijing 100084, China.

Proceedings of the National Academy of Sciences of the United States of America
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

Symbolic regression (SR) using large language models (LLM) and retrieval-augmented generation enables incremental learning. This SR-LLM framework effectively utilizes prior knowledge to discover complex, interpretable analytical models from data.

Keywords:
large language modelsretrieval-augmented generationsymbolic regression

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Area of Science:

  • Artificial Intelligence
  • Machine Learning
  • Data Science

Background:

  • Symbolic regression (SR) is crucial for discovering analytical models from data.
  • Existing SR algorithms struggle with vast search spaces, limiting complex expression discovery.
  • Deep learning advancements have renewed interest in SR for analytical modeling.

Purpose of the Study:

  • To introduce SR-LLM, a novel SR framework leveraging large language models (LLM) and retrieval-augmented generation for incremental learning.
  • To enhance the discovery of complex, interpretable analytical expressions by integrating prior knowledge.
  • To apply the framework to challenging domains like human car-following behavior analysis.

Main Methods:

  • SR-LLM integrates retrieval-augmented generation with LLMs for incremental learning.
  • The framework composes prior information into symbolic groups using LLMs.
  • Deep reinforcement learning combines these groups to formulate complex analytical expressions.

Main Results:

  • SR-LLM demonstrates superior performance on standard SR benchmarks.
  • The framework successfully rediscovers known car-following models from empirical data.
  • New analytical models for human car-following behavior were discovered, showing both effectiveness and interpretability.

Conclusions:

  • SR-LLM efficiently utilizes prior knowledge and past exploration for symbolic regression.
  • The framework facilitates the discovery of complex, human-understandable analytical models.
  • SR-LLM offers a powerful approach for scientific discovery in various domains, including behavioral analysis.