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Evaluation of the efficacy of modified low-dose HBO₂ therapy
Subhranshu Kumar1, Vishal Kansal2, Harsh Bir Singh Chaudhry3
1Senior Resident, INM, INHS Asvini, Mumbai.
Background:
The COVID-19 pandemic, being an airborne disease, posed a challenge in providing Hyperbaric Oxygen (HBO2) Therapy in multiplace chambers by increasing the risk of cross-infectivity while on air break inside the chamber. The standard regimen consisting of two air breaks was modified, and a new low-dose HBO₂ therapy regimen with no air breaks was introduced to mitigate the risk of cross- infection. This study aimed to evaluate the efficacy of the modified HBO₂ therapy regimen compared to the standard HBO2 therapy regimen for patients with soft tissue radiation injury.
Methods:
A retrospective observational study compared the modified low-dose HBO₂ therapy regimen of 2.4 Atmosphere Absolute (ATA) for 60 minutes without air-break vis-a-vis the standard regimen of 2.4 ATA for 100 minutes with two air breaks of five minutes each. Patients with soft tissue radiation injury in the form of radiation cystitis and radiation proctitis were selected for comparison in the study. Data was retrieved from patients who underwent the standard and modified regimen during the COVID-19 pandemic. Late Effects Normal Tissue (LENT)/ Subjective Objective Management Analytic (SOMA) questionnaire-based scoring was compared for 30 sessions of HBO₂ therapy. Standard biostatistical methodology was used to compare the outcomes of both regimens.
Results:
The mean LENT SOMA score decreased from the baseline to the end of 30 sessions in the HBO₂ therapy protocols. Overall, mean values decreased more for the patients who were offered the standard regimen of HBO₂ therapy.
Conclusion:
A modified low-dose HBO₂ therapy treatment regimen achieved statistically significant therapeutic benefits. However, the results were statistically more promising for the patients who underwent the standard HBO₂ therapy regimen.
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