Related Experiment Video
Updated: Jan 8, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Cannabis Use Among US Adolescents
Ryan S Sultan1,2,3, Alexander W Zhang1, Timothy D Becker1,2
1Department of Psychiatry/New York State Psychiatric Institute, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.
Cannabis use frequency in adolescents is linked to negative academic and emotional outcomes, even at low usage levels. These findings highlight the need for routine cannabis use screening in teens.
Area of Science:
- Adolescent development
- Cannabis use and mental health
- Psychosocial indicators
Background:
- Adolescence is a critical developmental stage.
- Limited data exists on dose-dependent cannabis use effects on adolescent psychosocial development, especially for infrequent users.
- Understanding these associations is crucial for targeted interventions.
Purpose of the Study:
- To examine the dose-dependent relationship between cannabis use frequency and psychosocial development indicators in adolescents.
- To identify specific adverse outcomes associated with varying levels of cannabis consumption.
- To inform public health strategies regarding adolescent cannabis use.
Main Methods:
- Cross-sectional study utilizing a nationally representative sample of US 8th, 10th, and 12th graders (2018-2022).
- Participants categorized into nonuse, noncurrent, monthly, weekly, and near-daily cannabis use groups.
- Demographically adjusted odds ratios and effect sizes calculated for psychosocial indicators.
Main Results:
- Over 26% of 162,532 students reported cannabis use.
- Noncurrent and monthly cannabis users showed increased odds of poor academic performance, impulsivity, self-regulation issues, and adverse emotional states compared to nonusers.
- A dose-response trend was observed for most adverse psychosocial outcomes, with younger users (<16 years) exhibiting greater susceptibility.
Conclusions:
- Dose-dependent associations between cannabis use frequency and adverse academic/emotional functioning are evident in adolescents, even with monthly use.
- These findings underscore the importance of routine cannabis use screening in adolescent healthcare.
- Early intervention and prevention efforts are critical to mitigate negative psychosocial impacts.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Hallucinogens and Psychedelics
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Cognitive Development During Adolescence

