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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Impact of therapeutic optimization in elderly multimorbid patients with heart failure and reduced ejection fraction
Gonzalo Martínez de Las Cuevas1, Cristina Baldeón Conde1, Sandra Merino Millán2
1Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Spain.
Background:
We evaluated the impact of a specialized unit on reducing heart failure (HF) readmissions in elderly patients with multiple comorbidities and HFrEF (LVEF < 40%) or mildly reduced EF (LVEF 40-50%), considering different levels of pharmacological optimization.
Methods:
Retrospective analysis of a cohort of 135 patients. Readmission rates and their association with optimized treatment were analyzed.
Results:
HF admissions decreased by 51% compared to the previous year (p = 0.013). Sixty percent received quadruple therapy, and 62-71% at least three drugs. NT-proBNP levels dropped by 70% (p < 0.001). Quadruple therapy was associated with fewer readmissions at 12 months (p = 0.036), as were ARNI + BB + MRA (p = 0.016) and MRA monotherapy (p = 0.012). The median time to achieve therapeutic optimization was 52 days (27-82 days).
Conclusions:
A specialized unit markedly improves therapeutic optimization and reduces readmissions in these patients.
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