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The pleiotropic effects of sotatercept
Giovanna Manzi1, Enrico Maggio1, Tommaso Recchioni1
1Department of Medical and Cardiovascular Sciences, Policlinico Universitario Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
None:
Recent randomized clinical trials (RCTs) have demonstrated the efficacy of sotatercept in the treatment of pulmonary arterial hypertension (PAH), leading to its approval by both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). This novel first-in-class fusion protein acts as a ligand trap for select members of the transforming growth factor-beta (TGF-β) superfamily, thereby exerting a broad spectrum of biological effects. These include vascular remodeling (via Activin A and B inhibition), enhancement of angiogenesis (through modulation of BMP-9), stimulation of erythropoiesis (by targeting GDF-11), and, to a lesser extent, modulation of skeletal muscle homeostasis (through GDF-8/myostatin inhibition). This review focuses on the pleiotropic effects of sotatercept, with the aim of encouraging the reader to delve deeper into the drug's multifaceted mechanisms.
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