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Labeling of Extracellular Vesicles for Monitoring Migration and Uptake in Cartilage Explants

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Bibliometric and LDA analysis of extracellular vesicles in osteoarthritis.

Hongyu Xie¹, Lin Zhao¹, Lunwei Kang¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.

|December 22, 2025

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This summary is machine-generated.

Extracellular vesicles show promise for osteoarthritis (OA) treatment. This bibliometric analysis maps research trends to guide future therapies and biomarker development for this degenerative joint disease.

Area of Science:

Biomedical Engineering
Regenerative Medicine
Osteoarthritis Research

Background:

Osteoarthritis (OA) is a prevalent degenerative joint disease with unclear mechanisms and limited treatment options.
Early symptoms are subtle, progression is irreversible, necessitating novel therapeutic strategies.
Extracellular vesicles (EVs) offer biocompatibility and low immunogenicity, presenting potential for drug delivery and acellular therapies in OA.

Purpose of the Study:

To systematically analyze global research on extracellular vesicles in osteoarthritis.
To identify key international collaborations, research hotspots, and emerging trends in the field.
To provide a scientific foundation for developing innovative OA treatments and clinical EV applications.

Main Methods:

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Bibliometric analysis

Latent Dirichlet Allocation (LDA) topic modeling

Systematic evaluation of scientific literature

Main Results:

Identified major research clusters and collaboration networks in the field of EVs and OA.
Highlighted current research hotspots and emerging trends in EV-based OA research.
Revealed the growing interest and potential of EVs as therapeutic agents for OA.

Conclusions:

Extracellular vesicles represent a promising avenue for osteoarthritis treatment and management.
Further research into EV mechanisms and clinical applications is warranted.
This study provides a comprehensive overview to guide future research and therapeutic development in OA.