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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Dissolvable microneedles (MNs) offer advanced dual-drug delivery for diseases like cancer and diabetes. Optimized designs enable precise, localized drug release, improving therapeutic outcomes and overcoming clinical translation challenges.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Microneedles (MNs) are minimally invasive platforms for transdermal drug delivery.
  • Dissolvable MNs are advancing dual-drug delivery with controlled dosage and release kinetics.

Purpose of the Study:

  • To review emerging strategies for dual-drug co-delivery using dissolving MNs.
  • To highlight how design parameters influence mechanical performance and drug release.
  • To discuss applications and future directions for MN-based dual-drug delivery.

Main Methods:

  • Review of recent advances in dual-drug delivery using dissolvable MNs.
  • Analysis of structural design, material composition, and release mechanisms.
  • Examination of dual-layer, core-shell, and stimuli-responsive MN configurations.

Main Results:

  • Dual-layer/core-shell MNs enable spatial and temporal drug separation.
  • Stimuli-responsive polymers allow drug release triggered by physiological cues (e.g., pH, ROS).
  • MNs demonstrated efficacy in cancer (anti-PD-L1/1-MT) and wound healing (MnSH/polymyxin B) models.

Conclusions:

  • Nanocarriers and responsive polymers enhance MN therapeutic potential for precise, localized, and sustained co-delivery.
  • Challenges include manufacturing, reproducibility, clinical validation, and regulatory approval.
  • Future research should focus on translating MN-based dual-drug delivery into clinical practice.