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Mycoplasma hominis infections in deep sternal wound infections post-cardiac surgery: insights from three case reports

Qimei Wei1, Rong Cong1, Tingting Liu2

  • 1Department of Clinical Laboratory, Wuhan Asia Heart Hospital, No.753 Jinghan Avenue, Jianghan District, Wuhan, 430022, People's Republic of China.

BMC Infectious Diseases
|December 22, 2025
PubMed
Abstract

Insights

Deep sternal wound infections (DSWIs) after cardiac surgery can be caused by Mycoplasma hominis. Early diagnosis and treatment with debridement and quinolone antibiotics are effective for these rare infections.

Area of Science:

  • Infectious Diseases
  • Cardiovascular Surgery
  • Microbiology

Background:

  • Deep sternal wound infections (DSWIs) are a growing concern post-cardiac surgery.
  • Factors like sternotomy site tension and obesity contribute to DSWI incidence.
  • Mycoplasma hominis, typically urogenital, can opportunistically infect surgical sites in at-risk patients.

Purpose of the Study:

  • To report cases of DSWIs caused by Mycoplasma hominis following cardiac surgery.
  • To highlight the clinical presentation and successful management of these infections.

Main Methods:

  • Case series reporting three patients with post-cardiac surgery DSWIs.
  • Clinical assessment including symptoms (fever, wound exudate) and laboratory tests (C-reactive protein).
  • Treatment involved surgical debridement and a minimum of two weeks of quinolone antibiotics.

Main Results:

  • Three cases of DSWIs attributed to Mycoplasma hominis were identified.
  • Patients presented with fever, clear wound exudate, and elevated C-reactive protein.
  • All patients responded well to surgical debridement and quinolone therapy.

Conclusions:

  • Mycoplasma hominis should be considered in the differential diagnosis of post-cardiac surgery DSWIs.
  • Prompt surgical intervention and appropriate antibiotic treatment are crucial for favorable outcomes.
  • Increased clinical vigilance is necessary for recognizing and managing these infections.
Keywords:
Mycoplasma hominisCase reportClear exudateDeep sternal wound infectionPost-cardiac surgery

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