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Risk stratification for CMV reactivation in sepsis patients: development of an interpretable machine learning model

Chengcheng Shen1, Yang Chen1, Tingting Pan2

  • 1Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.

BMC Infectious Diseases
|December 22, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
APACHE II scoreCD4+ lymphocyte countCMVCorticosteroid useICUInterpretable machine learningReactivationRisk stratificationSHAPSepsis

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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