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Related Experiment Video

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Application value of TPAS staining technique for cervical exfoliated cells in cervical cancer screening.

Guo Chen1, Wenli Zhang1, Yuchen HuYan1

  • 1Translational Medical Center, Shaanxi Provincial People' s Hospital, Xi'an, China.

Diagnostic Pathology
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

TPAS staining combined with HPV testing shows promise for cervical cancer diagnosis. This method offers higher accuracy and sensitivity compared to traditional tests, improving early detection rates.

Keywords:
Cervical cancer screeningHuman papillomavirus testing(HPV)Liquid-based thin-layer cell testing(TCT)TPAS staining

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Area of Science:

  • Oncology
  • Biotechnology
  • Medical Diagnostics

Background:

  • Tumor cell membranes have lower polarity than normal cells, a difference exploitable for cancer detection.
  • Viscosity-responsive plasma membrane probe (TPAS) staining targets membrane polarity for potential selective visualization of cervical cancer cells.
  • TPAS offers a novel approach for cervical cancer screening, complementing existing methods.

Purpose of the Study:

  • To investigate the diagnostic value of TPAS staining in detecting cervical cancer.
  • To evaluate TPAS in combination with liquid-based thin-layer cytological testing (TCT) and human papillomavirus (HPV) testing.
  • To compare the diagnostic performance of combined TPAS and HPV testing against TCT and HPV testing.

Main Methods:

  • A study involving 100 patients with suspected cervical precancerous lesions.
  • All patients underwent TPAS testing, HPV testing, and TCT.
  • Biopsy results served as the gold standard for assessing test positivity rates and diagnostic values.

Main Results:

  • TPAS exhibited an 86.7% detection rate, HPV 80%, and TCT 66.7%.
  • Combined TPAS + HPV testing achieved 72.00% accuracy and 70.6% sensitivity.
  • TPAS + HPV significantly outperformed TCT + HPV (58.0% accuracy, 54.1% sensitivity).

Conclusions:

  • TPAS combined with HPV testing demonstrates high specificity, sensitivity, and accuracy for cervical cancer diagnosis.
  • This combination represents a promising advancement for cervical cancer detection and screening.
  • The findings support the clinical utility of TPAS as a valuable tool in oncology diagnostics.