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Exploring the relationship between the severity of coronary artery lesions and depression levels

Beibei Li1, Yingzhi Zhu, Chen Chen

  • 1Department of Cardiology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.

Medicine
|December 23, 2025
PubMed

Insights

Coronary heart disease (CHD) patients with depression show higher coronary artery lesion severity and poorer sleep quality. Type D personality, poor sleep, and high red cell distribution width coefficient of variation (RDW-CV) are key factors linked to depression in CHD.

Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Medicine

Background:

  • Coronary heart disease (CHD) and depression frequently co-occur, complicating patient management.
  • Understanding the interplay between CHD severity and depression is crucial for effective treatment strategies.

Purpose of the Study:

  • To investigate the association between coronary artery lesion severity and depression levels in CHD patients.
  • To identify factors, including personality, sleep quality, and hematological markers, associated with depression in this population.

Main Methods:

  • A retrospective cohort study involving 106 CHD patients.
  • Assessment of coronary artery stenosis severity using the Gensini score.
  • Measurement of depression levels (SDS), Type D personality (DS14), sleep quality (PSQI), and red blood cell indices (RDW-CV, RBC, HGB).
  • Multivariate logistic regression analysis to determine independent predictors of depression.

Main Results:

  • Depressive patients exhibited significantly higher Gensini scores (indicating more severe coronary artery disease) and PSQI scores (worse sleep quality).
  • Higher prevalence of Type D personality was observed in the depressive group.
  • Significantly elevated RDW-CV and lower red blood cell count and hemoglobin (HGB) were found in CHD patients with depression.
  • Type D personality, high PSQI scores, and high RDW-CV were independently associated with depression.

Conclusions:

  • Depression is significantly associated with increased coronary artery disease severity and poorer sleep quality in CHD patients.
  • Type D personality, poor sleep quality, and elevated RDW-CV are key independent risk factors for depression in individuals with CHD.
  • These findings underscore the importance of screening for and managing depression, sleep disturbances, and Type D personality in CHD care.

Keywords:
coronary heart diseasedepressiongensini scorered cell distribution width coefficient of variationtype D personality

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