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Related Experiment Video

Updated: Jan 8, 2026

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Primary nodular pulmonary amyloidosis: A case report.

Chuchu Xu1, Xiaoqiong Wang1, Xiaona Yin1

  • 1Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China.

Medicine
|December 23, 2025
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Summary

Primary nodular pulmonary amyloidosis often presents asymptomatically and requires pathological confirmation. Early diagnosis is key for improving prognosis, despite limited treatment options for this rare lung condition.

Keywords:
CTCongo red stainingasymptomaticprimary nodular pulmonary amyloidosis

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Area of Science:

  • Pulmonology
  • Pathology
  • Radiology

Background:

  • Primary nodular pulmonary amyloidosis is a rare condition.
  • It involves the deposition of amyloid in the lungs, forming nodules.
  • Understanding its etiology, pathogenesis, and clinical course is essential.

Purpose of the Study:

  • To report a case of primary polymorphic pulmonary amyloidosis.
  • To highlight the diagnostic challenges and importance of pathological confirmation.
  • To discuss the implications for patient prognosis.

Main Methods:

  • Retrospective analysis of a single patient diagnosed with primary polymorphic pulmonary amyloidosis.
  • Utilized chest computed tomography (CT), bronchoscopy with transbronchial needle aspiration, cone beam CT, and endoscopic ultrasound (EBUS).
  • Pathological examination included polymorphic plasma cell infiltration, giant cell proliferation, and Congo red staining.

Main Results:

  • The patient was asymptomatic with incidental pulmonary nodules detected on CT.
  • Diagnosis was confirmed via pathological examination and positive Congo red staining.
  • Primary nodular pulmonary amyloidosis lacks specific clinical and imaging features.

Conclusions:

  • Asymptomatic presentation is possible for primary nodular pulmonary amyloidosis.
  • Rigorous diagnostic procedures, including pathological confirmation, are necessary.
  • Early detection is critical for prognosis, even with limited treatment options.