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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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Artifact-free partial volume correction for 177Lu-PSMA SPECT.

Yibin Liu1, Zhonglin Lu1,2, Gefei Chen1,3

  • 1Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau, SAR, China.

Medical Physics
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

This study developed a spatially variant point spread function (svPSF) enhanced partial volume correction (PVC) for 177Lu-PSMA SPECT imaging. The novel method significantly improves quantification accuracy without introducing Gibbs ringing artifacts or noise amplification.

Keywords:
177Lu‐PSMA‐617SPECT/CTpartial volume correctionspatially variant point spread function

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiopharmaceutical Therapy

Background:

  • Partial volume effect (PVE) in SPECT imaging reduces quantification accuracy.
  • Traditional partial volume correction (PVC) methods often use spatially invariant point spread functions (PSFs) and can introduce Gibbs ringing artifacts.

Purpose of the Study:

  • To develop a spatially variant PSF (svPSF) enhanced PVC for 177Lu-PSMA SPECT.
  • To achieve improved quantification accuracy without Gibbs ringing or noise amplification.

Main Methods:

  • Generated svPSFs via Monte Carlo simulations and linear interpolation.
  • Enhanced Reblurred Van Cittert (RVC) and iterative Yang (IY) algorithms with svPSFs, voxel by voxel.
  • Implemented non-negativity constraint (NC) in RVC to mitigate artifacts.
  • Validated methods using simulated (cylindrical and XCAT phantoms) and real clinical 177Lu-PSMA-617 SPECT data.

Main Results:

  • svPSF-enhanced PVC methods improved recovery coefficients (RC) for phantom spheres.
  • Mean absolute errors (MAE) in kidneys, parotid glands, and tumors were significantly reduced, e.g., from 51.8% to 8.8% for tumors.
  • The proposed svPSF+NC-RVC method showed improved background uniformity (CoV of 0.082).
  • Gibbs ringing artifacts and noise were reduced with NC implementation in RVC.

Conclusions:

  • The developed svPSF enhanced PVC methods enhance quantification accuracy in 177Lu-PSMA-617 SPECT.
  • Non-negativity constraint (NC) effectively suppresses Gibbs ringing artifacts and noise in RVC images.