Efficacy of Submucosal Polydeoxyribonucleotide Injection after Impacted Mandibular Third Molar Extraction: A...

Area of Science:

• Oral and Maxillofacial Surgery
• Regenerative Medicine

Background:

• Impacted mandibular third molar (IMTM) extraction is a common surgical procedure.
• Postoperative complications such as pain and swelling can significantly impact patient recovery.

Purpose of the Study:

• To evaluate the efficacy of polydeoxyribonucleotide (PDRN) injections in mitigating postoperative complications following IMTM extraction.
• To assess the impact of PDRN on pain, swelling, periodontal pocket depth, and patient-reported outcomes.

Main Methods:

• A randomized, controlled clinical trial involving 30 patients undergoing bilateral IMTM extraction.
• PDRN was injected on one side (experimental), while normal saline was administered on the contralateral side (control).
• Outcomes measured included visual analog scale for pain, Laskin method for swelling, 3D volumetric analysis, periodontal probing depth, and patient-centered outcome questionnaires.

Main Results:

• Statistically significant reductions in postoperative pain and swelling were observed on the PDRN-treated side compared to the control side.
• PDRN demonstrated a positive effect in reducing patient discomfort and improving subjective perceptions of recovery.

Conclusions:

• PDRN injection appears to be a viable option for reducing postoperative pain and swelling after IMTM extraction.
• Further randomized controlled trials are warranted to confirm these findings and establish PDRN's clinical utility.