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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Accelerating evidence generation to implementation: Establishment of the Leading Awareness to Action through
Laney K Jones1, Ty J Gluckman2, Ankeet S Bhatt3,4
1Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, USA.
Abstract:
Recent scientific advancements have led to the availability of innovative therapies to reduce the risk of cardiometabolic events, offering new tools to address the world's leading cause of mortality. The length of time from evidence generation to implementation in healthcare settings remains far from optimal, resulting in missed opportunities to improve morbidity and mortality and unrealized population-level benefit. Established in 2023, the Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE™) consortium's mission is to unite partners dedicated to improving cardiometabolic health by creating an inclusive platform for sharing evidence-based tools, methodologies, and strategies to address gaps in care at scale. The LATTICE consortium aims to accomplish this by 1) exploring novel strategies for translating evidence-based advancements across diverse clinical practice settings and 2) disseminating successful strategies through a unique collaboration among clinicians, healthcare systems, payors, patients, patient advocacy groups, and life science companies. The LATTICE consortium is prioritizing projects that rigorously test strategies grounded in implementation science and hold significant promise for uptake at scale. Success of the LATTICE consortium will be assessed through improved awareness, access, and implementation of effective, scalable, and sustainable health care strategies that address cardiometabolic gaps in care.
Insights
The Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE™) consortium accelerates the adoption of new cardiometabolic therapies. This initiative bridges the gap between evidence and practice to improve patient outcomes and reduce mortality.
Area of Science:
- Cardiology
- Metabolic Disorders
- Implementation Science
Background:
- Cardiovascular disease and metabolic disorders are leading causes of mortality globally.
- Translating scientific advancements into clinical practice is often slow, limiting patient benefit.
- The gap between evidence generation and healthcare implementation necessitates scalable solutions.
Purpose of the Study:
- To establish the Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE™) consortium.
- To create a collaborative platform for sharing evidence-based tools and strategies for cardiometabolic health.
- To accelerate the implementation of innovative therapies to reduce cardiometabolic events.
Main Methods:
- Exploring novel strategies for translating evidence-based advancements into diverse clinical settings.
- Disseminating successful strategies through collaboration among stakeholders (clinicians, payors, patients, industry).
- Prioritizing projects that rigorously test implementation science strategies for scalability.
Main Results:
- The LATTICE consortium was established in 2023 to unite partners focused on improving cardiometabolic health.
- The consortium facilitates the sharing of tools, methodologies, and strategies to address care gaps.
- Focus on scalable and sustainable healthcare strategies for widespread adoption.
Conclusions:
- The LATTICE consortium aims to improve awareness, access, and implementation of effective cardiometabolic care strategies.
- Successful implementation will lead to reduced morbidity and mortality from cardiometabolic events.
- Collaboration and implementation science are key to achieving population-level benefit in cardiometabolic health.
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