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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

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Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

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Published on: March 1, 2024

The dysregulation score method identifies epigenetic regulator genes that predict cancer prognosis and efficiency of

Jie Lyu^1,2,3, Hao Zhang^1,2, Jinjin Zhong^2,3

¹College of Information and Engineering, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang, People's Republic of China.

Molecular Therapy. Nucleic Acids

|December 23, 2025

Summary

This summary is machine-generated.

Researchers identified 272 cancer-specific epigenetic regulator (ER) genes dysregulated in cancer. These genes, including novel ones, show potential as biomarkers for prognosis and immunotherapy response in precision oncology.

Keywords:

MT: Bioinformatics cancer cancer therapy epigenetic regulator medicine target prognosis

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Last Updated: Jan 8, 2026

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Area of Science:

Molecular Biology
Genetics
Cancer Research

Background:

Epigenetic mechanisms are vital in cancer development.
Over 600 epigenetic regulator (ER) genes are poorly understood in human cancers.
ER genes control DNA and histone modifications.

Purpose of the Study:

Identify and characterize cancer-specific dysregulated ER genes.
Investigate the role of novel dysregulated ER genes (DEGs) in cancer.
Evaluate DEGs as prognostic and predictive biomarkers for cancer therapy.

Main Methods:

Analyzed over 19,000 paired tumor-normal human samples.
Developed a dysregulation score to identify cancer-specific ER genes.
Validated novel DEGs in melanoma cell lines for proliferation and invasion roles.

Main Results:

Identified 272 cancer-specific dysregulated ER genes.
Discovered four novel DEGs involved in melanoma cell proliferation and invasion.
DEG signature scores predict patient prognosis across various cancer types.
DEGs combined with immune checkpoints improve immunotherapy prediction.

Conclusions:

Dysregulated ER genes are significant in cancer initiation and progression.
Novel DEGs offer potential therapeutic targets and prognostic indicators.
This DEG list supports translational research and precision oncology development.