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Non-antibiotic nanoplatform based CuS/AuNCs@Lip NPs for inhibition pneumonia caused by MRSA and its mechanism
Qing Fan1, Xinzhong Zhang1, Sai Zhang1
1School of Pharmacy, Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, PR China.
Abstract:
Methicillin-resistant Staphylococcus aureus (MRSA) is a major threat to human health due to its multi-antibiotic resistance, either intrinsic or acquired. One of the acquired mechanisms lies in MRSA biofilms, which shield bacteria from antibiotic eradication, contributing to chronic infections. To address this challenge, we constructed the novel non-antibiotic nano-delivery platforms based on copper sulfide/gold nanocluster@liposomes nanoparticles (CuS/AuNCs@Lip NPs). Upon the excitation of 1064 nm near-infrared light, these NPs exhibit excellent photothermal effect and reactive oxygen species (ROS) generation ability, destroying the structure of bacterial membrane to kill MRSA and removing biofilm effectively. In vivo experiments demonstrated the target enrichment at infection sites, significant therapeutic efficacy in the subcutaneous cyst and pneumonia models caused by MRSA in mice, and a favorable biosafety profile. This study provides novel non-antibiotic strategies for treating drug-resistant bacterial infections that combine efficient antimicrobial properties with biosafety.
Insights
Novel nanoparticles effectively combat antibiotic-resistant MRSA infections. These non-antibiotic platforms utilize photothermal and ROS effects to eradicate bacteria and biofilms, showing promise for treating drug-resistant infections.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Infectious Diseases
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant global health threat due to its multidrug resistance.
- Bacterial biofilms produced by MRSA contribute to persistent infections and resistance to antibiotic treatments.
Purpose of the Study:
- To develop and evaluate novel non-antibiotic nano-delivery platforms for combating MRSA infections.
- To investigate the efficacy of copper sulfide/gold nanocluster@liposomes nanoparticles (CuS/AuNCs@Lip NPs) in eradicating MRSA and its biofilms.
Main Methods:
- Construction of CuS/AuNCs@Lip NPs as a nano-delivery platform.
- Utilizing 1064 nm near-infrared light to induce photothermal effects and reactive oxygen species (ROS) generation.
- Evaluating the antimicrobial activity against MRSA and biofilm disruption in vitro and in vivo.
Main Results:
- CuS/AuNCs@Lip NPs demonstrated potent photothermal and ROS generation capabilities upon near-infrared light irradiation.
- Effective destruction of bacterial membranes, killing MRSA, and removal of biofilms were observed.
- In vivo studies showed targeted accumulation at infection sites, significant therapeutic effects in murine models of MRSA subcutaneous cyst and pneumonia, and a good biosafety profile.
Conclusions:
- The developed CuS/AuNCs@Lip NPs represent a promising non-antibiotic strategy for treating drug-resistant bacterial infections.
- This approach effectively combines antimicrobial properties with enhanced biosafety, offering a novel therapeutic avenue against MRSA.
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