Enzyme-Responsive Polymeric Materials with Anticancer and Antibacterial Activities.

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Biomedical Engineering

Background:

• Enzymes catalyze biochemical reactions with high selectivity and efficiency.
• Enzyme-responsive polymers (ERPs) leverage these enzymatic properties for therapeutic applications.
• Polymeric materials offer biocompatibility and tunable properties for drug delivery systems.

Purpose of the Study:

• To review recent advancements (2014-present) in enzyme-responsive polymers for anticancer and antibacterial therapies.
• To identify underexplored enzymes with potential for novel ERP design.
• To guide the predictable application of ERPs in addressing biomedical challenges.

Main Methods:

• Literature review of recent scientific publications (2014-present).
• Analysis of enzyme-responsive polymer applications in oncology and infectious diseases.
• Identification and discussion of emerging enzymes for future ERP development.

Main Results:

• Significant progress has been made in developing ERPs for targeted cancer and antibacterial treatments.
• Several promising enzymes, previously underexplored, show potential for innovative ERP design.
• Recent advancements demonstrate the efficacy of ERPs in enhancing therapeutic outcomes.

Conclusions:

• Enzyme-responsive polymers represent a powerful platform for advanced therapeutic strategies.
• Further exploration of novel enzymes can unlock new possibilities in ERP-based biomedical applications.
• Predictable design of ERPs is crucial for overcoming critical healthcare challenges.