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Nonsteroidal Anti-Inflammatory Drug-Induced Granulomatous Interstitial Nephritis in Juvenile Idiopathic Arthritis: A
Chakraborti Annesha1, Swarnim Swarnim1, Mantan Mukta1
1Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
Abstract:
Granulomatous interstitial nephritis (GIN) is rare in childhood and is associated with poor outcomes. We report a 6-year-old girl who developed nephrotic-range proteinuria following chronic non-steroidal anti-inflammatory drug (NSAID) use for juvenile idiopathic arthritis (JIA). Other possible etiologies were ruled out, and the diagnosis of GIN was confirmed by renal biopsy. NSAIDs were henceforth withheld and prednisolone was started, which resulted in amelioration of proteinuria. Strong suspicion, quick diagnosis and early initiation of therapy improve the outcome in GIN and prevents or delays kidney failure.
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