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Anti-phospholipase A2 Receptor-associated Membranous Nephropathy in an Adolescent Boy with HLA-B27-positive Juvenile
Sudeep Patel1, Divyesh Engineer1, Himanshu Patel1
1Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences, Civil Hospital, Ahmedabad, India.
Abstract:
Juvenile idiopathic arthritis is common rheumatic disease in children and adolescents, but renal involvement is uncommon. Renal involvement is mostly in the form of secondary renal amyloidosis presenting as proteinuria. Membranous nephropathy is an uncommon renal manifestation of juvenile idiopathic arthritis. Here, we report a case of HLA-B27-positive oligoarticular juvenile idiopathic arthritis presenting as subnephrotic proteinuria. The patient also had positive anti-phospholipase A2 receptor antibodies in the serum as well as in the glomeruli according to the immunohistochemistry assay. The patient achieved clinical remission with steroids and mycophenolate sodium.
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