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Updated: Sep 20, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Antiviral activity of benzothiazole and benzothiazolinethione derivatives in cell cultures
Abstract:
The virus inhibitory activity of benzothiazole, benzothiazolinethione and naphthothiazole derivatives was tested with vaccinia virus, Newcastle disease virus (NDV) and western equine encephalomyelitis (WEE) virus in the agar-diffusion plaque-inhibition test. Among 58 compounds examined, 5 showed medium activity and selectivity with vaccinia virus. The highest selective effect was found with 3-(2-ethylthio-6-benzothiazolylaminomethyl)-2-benzothiazolinethione. A much lower inhibitory effect was observed with several derivatives against WEE virus. One derivative (2-mercaptobenzothiazole) showed a low inhibitory effect against NDV.
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