Magnesium Structure-Function Integration Platform for Spatiotemporal Multi-Modality Therapy: Combining Hormonotherapy...

Area of Science:

• Biomaterials Science
• Immunotherapy
• Drug Delivery Systems
• Prostate Cancer Research

Background:

• Metal-based immunotherapy shows promise but faces clinical hurdles like poor drug delivery, specificity, and efficacy.
• Existing treatments for prostate cancer often require improved strategies for targeted delivery and synergistic therapeutic effects.

Purpose of the Study:

• To develop an implantable therapeutic platform on a magnesium (Mg) surface for enhanced prostate cancer immunotherapy.
• To improve structural stability, achieve spatiotemporal drug release, and combine immune-hormone therapy for better treatment outcomes.

Main Methods:

• Constructed a therapeutic platform using magnesium (Mg) surface, self-healing thiolated hyaluronic acid (HA-SH), and cell membrane-derived vesicles (CMV).
• Utilized CMV for phospholipid bilayer interactions, HA-SH disulfide bonds, and glutathione (GSH)-responsive drug release.
• Integrated ginsenoside Rb1 for androgen receptor signaling inhibition and Mg for hydrogen release, targeting PI3K-AKT pathway.

Main Results:

• The platform demonstrated enhanced structural stability, mitigated corrosion, and enabled spatiotemporal drug release.
• Ginsenoside Rb1 effectively inhibited androgen receptor signaling, while Mg release induced immunogenic cell death and tertiary lymphoid structures (TLS) formation.
• Achieved synergistic androgen deprivation therapy and immune activation, demonstrating improved therapeutic efficacy.

Conclusions:

• The developed implantable drug delivery system addresses mechanical stability, local drug delivery, and systemic immune activation challenges.
• This platform shows significant translational potential for treating various malignancies by enhancing treatment effectiveness and reducing structural failure risks.