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Trained Immunity: RoadMap for drug discovery and development.

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This review offers a roadmap for developing therapeutics targeting Trained Immunity, a form of innate immune cell memory. It guides researchers in identifying targets and advancing Trained Immunity therapies from discovery to clinical application.

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Area of Science:

  • Immunology
  • Innate immunity
  • Drug discovery

Background:

  • Trained Immunity involves nonspecific memory in innate immune cells.
  • This memory alters responses to secondary stimulation.
  • Developing therapeutics for Trained Immunity requires a structured approach.

Purpose of the Study:

  • To provide a roadmap for discovering and developing therapeutics targeting Trained Immunity.
  • To guide researchers with scientific backgrounds but limited drug development experience.
  • To bridge the gap between scientific discovery and clinical application in Trained Immunity.

Main Methods:

  • Outlines five drug development domains: epigenetic, metabolic, differentiation, inflammatory, and memory changes.
  • Emphasizes preclinical models and artificial intelligence for target discovery and screening.
  • Addresses challenges in translating preclinical findings to clinical trials.

Main Results:

  • Identifies key areas for molecular target identification and biomarker development.
  • Highlights the application of AI and preclinical models in drug discovery.
  • Discusses disease indications and ongoing clinical trials in the field.

Conclusions:

  • The review integrates scientific findings with development strategy.
  • It aims to advance the field of Trained Immunity-based therapeutics.
  • Facilitates the translation of research into clinical practice.