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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 8, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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[Neuroprotective therapy in advanced primary open-angle glaucoma].

D A Dorofeev1,2, I V Kozlova1, A I Vereshchagina3

  • 1Krasnov Research Institute of Eye Diseases, Moscow, Russia.

Vestnik Oftalmologii
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Retinalamin therapy in advanced primary open-angle glaucoma (POAG) patients demonstrated a slower decline in visual field and retinal nerve fiber layer thickness compared to controls. Regular administration with stable intraocular pressure is key for neuroretinoprotective benefits.

Keywords:
glaucomaretinal protectionretinalamin

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Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Advanced glaucoma necessitates strategies to slow disease progression and preserve visual function.
  • Neuroprotective agents are being investigated to complement traditional IOP management.

Purpose of the Study:

  • To evaluate the long-term effects of Retinalamin on visual analyzer structure and function in advanced POAG.
  • To assess the efficacy of regular Retinalamin administration in slowing glaucoma progression.
  • To determine if Retinalamin offers neuroretinoprotective benefits in patients with controlled intraocular pressure.

Main Methods:

  • A prospective, multicenter cohort study involving 56 patients (98 eyes) with advanced POAG.
  • Patients received regular intramuscular injections of Retinalamin (5 mg) every three months for two years.
  • A control group received standard care without neuroprotective therapy; all patients maintained stable intraocular pressure (IOP).

Main Results:

  • The Retinalamin group showed a slower rate of visual field mean deviation (MD) decline (0.98 dB/year) compared to the control group (1.65 dB/year).
  • Retinal nerve fiber layer (RNFL) thickness decreased minimally (1.5 μm/year) in the Retinalamin group versus a more pronounced decrease (3.0 μm/year) in the control group.
  • Pattern standard deviation (PSD) changes indicated slower visual field deterioration in the Retinalamin group.

Conclusions:

  • Long-term, regular Retinalamin therapy is beneficial for patients with advanced POAG.
  • Neuroretinoprotection with Retinalamin is effective when IOP is stable and well-controlled.
  • Retinalamin therapy can help preserve visual function and slow structural damage in advanced glaucoma.