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Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post-Functionalization
Liting He1, Haiyan Zhou1, Qiushi Chen1,2
1Department of Chemistry, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.
None:
Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli-responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to the intrinsic limitation of cationic polymerization. Herein, we developed a post-functionalization approach to achieve water-soluble cPPA derivatives with high molecular weight. The cPPA modified with cell-penetrating oligoarginine underwent cellular uptake via endocytosis and acid-triggered depolymerization in lysosome, which provided new potential for biological application.
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