Exploring the association between BMI and liver fat in children: a study using ultrasound-derived fat fraction (UDFF)
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View abstract on PubMed
Summary
This summary is machine-generated.Childhood obesity is linked to increased liver fat in children. Ultrasound-derived fat fraction (UDFF) shows a positive correlation with BMI z-score, indicating higher hepatic fat content in overweight children.
Area Of Science
- Pediatric Gastroenterology
- Hepatology
- Medical Imaging
Background
- Childhood obesity is a growing global health concern.
- Metabolic dysfunction-associated steatotic liver disease is the most common liver condition in children.
- Ultrasound-derived fat fraction (UDFF) offers a non-invasive method for quantifying liver fat.
Purpose Of The Study
- To investigate the relationship between body mass index (BMI) z-score and UDFF in children.
- To assess UDFF in pediatric patients without pre-existing liver conditions.
Main Methods
- Retrospective analysis of abdominal ultrasounds with UDFF measurements.
- Classification of participants into normal weight and overweight categories based on BMI z-score.
- Statistical analysis including chi-square tests, Pearson's correlation, and logistic regression to evaluate associations between UDFF, BMI z-score, abdominal wall thickness (AWT), and ethnicity.
Main Results
- Overweight children exhibited a significantly higher prevalence of elevated UDFF compared to normal-weight children.
- UDFF demonstrated a positive correlation with BMI z-score.
- Ultrasound-measured abdominal wall thickness (AWT) emerged as the strongest independent predictor of elevated UDFF in multivariable analysis.
Conclusions
- BMI z-score is positively associated with hepatic fat content and elevated UDFF in children.
- Abdominal wall thickness is a key indicator of hepatic fat accumulation in pediatric patients.
- UDFF shows promise as a complementary tool for early detection of pediatric hepatic steatosis.
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