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Markers of fibrosis in orbital tissues from patients graves' orbitopathy: a retrospective cohort study

Giovanna Rotondo Dottore1, Liborio Torregrossa2, Elena Sabini1

  • 1Department of Clinical and Experimental Medicine, Endocrinology Units, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Journal of Endocrinological Investigation
|December 23, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CollagenFibronectinFibrosisGraves’ orbitopathyThyroid eye disease

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Graves Disease II: Pathophysiology01:24

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Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

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