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Basic Science and Pathogenesis.

Carlos Javier Pomilio1,2, Ángeles Vinuesa1,2, Jessica L Presa2,3

  • 1CONICET, Buenos Aires, Argentina.

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|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Elevated Galectin-1 (Gal-1) levels in Alzheimer

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Area of Science:

  • Neuroscience
  • Immunology
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is a growing global health concern, necessitating early detection and new treatments.
  • Elevated cerebrospinal fluid Galectin-1 (Gal-1) levels are identified in AD patients, correlating with disease biomarkers.
  • Increased Gal-1 is a risk factor for progression from mild cognitive impairment to AD dementia.

Purpose of the Study:

  • To investigate the role of Galectin-1 (Gal-1) in Alzheimer's disease (AD) pathogenesis.
  • To explore Gal-1's potential as a therapeutic target for AD.

Main Methods:

  • Analysis of post-mortem AD brain tissue and transgenic mouse models (PDAPPJ20).
  • In vitro and in vivo studies on Gal-1 modulation of microglia and amyloid-beta (Aβ) phagocytosis.
  • Administration of Gal-1 to aged AD mice, followed by transcriptomic analysis and cognitive assessment.

Main Results:

  • Gal-1 modulates microglia, inducing a deactivated state and restoring Aβ phagocytosis.
  • Gal-1 administration reduced amyloid burden and improved cognition in aged AD mice.
  • Gal-1 therapy promoted neuroprotective pathways and a less inflammatory brain environment.

Conclusions:

  • Galectin-1 plays a significant role in Alzheimer's disease pathology and progression.
  • Gal-1 facilitates Aβ clearance and exhibits neuroprotective effects.
  • A glycosylation-dependent pathway involving Gal-1 presents a promising therapeutic strategy for AD.