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Harnessing AMPs to Tackle ESKAPE Pathogens
Verma Surabhi1, Vijendra Prabhu2, Usha Yogendra Nayak3
1Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, 576104 Manipal, India.
Abstract:
The widespread and rapid dissemination of antimicrobial resistance (AMR) is a global burden, and its consequences, especially in healthcare settings, are threatening. ESKAPE pathogens, a group of common nosocomial bacteria, have developed high levels of resistance to multiple antibiotics, leading to adverse effects, such as increased morbidity and mortality. As a result, there is an urgent need for effective strategies to combat AMR. Among the various available strategies, antimicrobial peptides (AMPs) have emerged as a promising approach to deal with AMR. This review elaborates on the diverse nature of AMPs and their applications, with a particular focus on ESKAPE pathogens. It also provides an overview of the current status of AMP research including both in vitro and in vivo studies and explores their potential in combination therapies against drug-resistant pathogens. The current challenges and future prospects of using AMPs in a clinical setting have also been discussed to acknowledge the gap between laboratory research and clinical application.
Insights
Antimicrobial peptides (AMPs) offer a promising strategy against drug-resistant ESKAPE pathogens, a major healthcare threat. Research explores AMPs
Area of Science:
- Microbiology
- Biochemistry
- Pharmacology
Background:
- Antimicrobial resistance (AMR) is a significant global health threat, particularly in healthcare.
- ESKAPE pathogens are multidrug-resistant nosocomial bacteria causing increased morbidity and mortality.
- Novel strategies are urgently needed to combat the rising challenge of AMR.
Purpose of the Study:
- To review the diverse nature and applications of antimicrobial peptides (AMPs).
- To focus on the potential of AMPs against ESKAPE pathogens.
- To explore AMPs in combination therapies and discuss clinical translation challenges.
Main Methods:
- Literature review of existing research on AMPs.
- Analysis of in vitro and in vivo studies concerning AMP efficacy.
- Examination of current challenges and future prospects for clinical application.
Main Results:
- Antimicrobial peptides (AMPs) demonstrate significant potential against multidrug-resistant ESKAPE pathogens.
- AMPs show promise in both monotherapy and combination therapy approaches.
- Existing research highlights the need for further investigation into clinical applications.
Conclusions:
- AMPs represent a viable and promising therapeutic avenue for combating AMR, especially against ESKAPE pathogens.
- Further research and development are crucial to bridge the gap between laboratory findings and clinical practice for AMPs.
- Combination therapies involving AMPs may offer enhanced efficacy against drug-resistant infections.
