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Related Concept Videos

Amplifying Signals via Enzymatic Cascade01:22

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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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Related Experiment Video

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Electroporation of Mycobacteria
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Harnessing AMPs to Tackle ESKAPE Pathogens.

Verma Surabhi1, Vijendra Prabhu2, Usha Yogendra Nayak3

  • 1Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, 576104 Manipal, India.

ACS Infectious Diseases
|December 23, 2025
PubMed
Summary

Antimicrobial peptides (AMPs) offer a promising strategy against drug-resistant ESKAPE pathogens, a major healthcare threat. Research explores AMPs

Keywords:
ESKAPE pathogensantimicrobial peptidesantimicrobial resistancedrug-resistantnosocomial bacteria

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Area of Science:

  • Microbiology
  • Biochemistry
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) is a significant global health threat, particularly in healthcare.
  • ESKAPE pathogens are multidrug-resistant nosocomial bacteria causing increased morbidity and mortality.
  • Novel strategies are urgently needed to combat the rising challenge of AMR.

Purpose of the Study:

  • To review the diverse nature and applications of antimicrobial peptides (AMPs).
  • To focus on the potential of AMPs against ESKAPE pathogens.
  • To explore AMPs in combination therapies and discuss clinical translation challenges.

Main Methods:

  • Literature review of existing research on AMPs.
  • Analysis of in vitro and in vivo studies concerning AMP efficacy.
  • Examination of current challenges and future prospects for clinical application.

Main Results:

  • Antimicrobial peptides (AMPs) demonstrate significant potential against multidrug-resistant ESKAPE pathogens.
  • AMPs show promise in both monotherapy and combination therapy approaches.
  • Existing research highlights the need for further investigation into clinical applications.

Conclusions:

  • AMPs represent a viable and promising therapeutic avenue for combating AMR, especially against ESKAPE pathogens.
  • Further research and development are crucial to bridge the gap between laboratory findings and clinical practice for AMPs.
  • Combination therapies involving AMPs may offer enhanced efficacy against drug-resistant infections.