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Stuart William Mitchell1,2, Tevy Chan1,2,3, Lydia Trudel1,2,3,4,5,6,7

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Summary
This summary is machine-generated.

Spatial extent of tauopathy (SEOT) better predicts cognitive decline in Alzheimer's disease than tau load (SUVR). SEOT may be a more sensitive marker for neurodegenerative disease progression.

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Area of Science:

  • Neuroimaging
  • Alzheimer's Disease Research
  • Cognitive Neuroscience

Background:

  • Brain and cognitive resilience (BR, CR) are key to maintaining function despite Alzheimer's disease (AD) tau pathology.
  • Tau pathology can be measured by spatial extent (SEOT) or load (SUVR).
  • Understanding factors influencing BR and CR is crucial for AD management.

Purpose of the Study:

  • Compare SEOT and SUVR in their association with BR and CR.
  • Replicate previous findings using MK-6240 PET imaging.
  • Evaluate demographic, genetic, and imaging factors linked to BR and CR.

Main Methods:

  • 126 amyloid-β-positive participants from the TRIAD cohort underwent tau-PET ([18F]MK6240) and cognitive assessments (MMSE).
  • SEOT was quantified as the proportion of voxels with abnormal tau deposition relative to young controls.
  • Participants included individuals with mild cognitive impairment (MCI) or AD.

Main Results:

  • Higher Whole Cortex MK SUVR correlated with lower MMSE scores, indicating tau pathology is linked to cognitive decline.
  • MCI patients showed higher MMSE scores despite some tau accumulation compared to AD patients.
  • Whole Cortex SEOT demonstrated a stronger negative correlation with MMSE than SUVR, suggesting SEOT is more sensitive to cognitive decline.

Conclusions:

  • Whole Cortex SEOT is a more sensitive marker of cognitive decline in AD and MCI than Whole Cortex MK-6240 SUVR.
  • SEOT shows a stronger association with cognitive impairment progression.
  • Further research is warranted to validate SEOT as a biomarker for neurodegenerative conditions.