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Alzheimer's Imaging Consortium.

Pamela C L Ferreira1, Tevy Chan2, Bruna Bellaver1

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Summary
This summary is machine-generated.

Plasma phosphorylated tau (p-tau) at threonine 217 shows strong associations with four tau PET tracers, aiding Alzheimer's disease diagnosis. These findings support p-tau217 as a reliable biomarker for detecting tau pathology.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Alzheimer's Disease Research

Background:

  • Tau phosphorylation and aggregation are key indicators of Alzheimer's disease (AD) pathology.
  • Plasma phosphorylated tau (p-tau) at threonine 217 (p-tau217) has shown promise in detecting AD-related tau tangle pathology.

Purpose of the Study:

  • To conduct a head-to-head comparison of plasma p-tau217 with four distinct tau PET tracers: MK6240, Flortaucipir (FTP), PI2620, and RO948.
  • To explore the association between plasma p-tau217 levels and tau PET tracer binding in individuals across the AD continuum.

Main Methods:

  • Studied 338 individuals (cognitively unimpaired, mild cognitive impairment, dementia) with available plasma p-tau217 and tau PET tracers (FTP, MK6240).
  • A subset of 64 individuals also had PI2620 and RO948 data.
  • Assessed association strength using regression models and quantified variance explained by plasma p-tau217.

Main Results:

  • Plasma p-tau217 demonstrated robust associations with all four tau PET tracers in similar topographical regions.
  • MK6240 showed a slightly higher extent and magnitude of association with plasma p-tau217 compared to other tracers.
  • Plasma p-tau217 explained a significant proportion of the variance in tau PET tracer estimates, with variations across tracers.

Conclusions:

  • The four studied tau PET tracers exhibit strong associations with plasma p-tau217.
  • These findings reinforce the utility of plasma p-tau217 as a biomarker for assessing tau pathology in Alzheimer's disease.