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Updated: Jan 8, 2026

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Alzheimer's Imaging Consortium.

Michelle R Caunca1, Amber L Bahorik2, Xiaqing Jiang2

  • 1Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Neuroimaging markers for dementia, including amyloid and tau deposition, differ by race/ethnicity and gender. Cardiovascular risk partially mediates these differences, particularly for white matter hyperintensity in Black individuals.

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Area of Science:

  • Neuroimaging
  • Dementia Research
  • Health Disparities

Background:

  • Emerging data show race/ethnicity and gender influence dementia pathology and cardiovascular risk.
  • This study investigates how these factors impact neuroimaging markers of dementia.

Purpose of the Study:

  • To examine racial/ethnic and gender differences in neuroimaging markers of cerebrovascular disease and neurodegeneration.
  • To determine if cardiovascular risk partially mediates these associations.

Main Methods:

  • Utilized Health and Brain Study-Health Disparities (HABS-HD) data from dementia-free participants.
  • Employed linear and multinomial regression, adjusting for demographic and socioeconomic factors.
  • Incorporated Framingham Risk Score (FRS) to assess mediation by cardiovascular risk.

Main Results:

  • Women of color exhibited higher odds of intermediate/high cardiovascular risk.
  • Black participants showed lower amyloid-beta deposition but higher white matter hyperintensity volume (WMHV).
  • Women of color had greater medial temporal tau deposition; FRS partially mediated WMHV in Black women.

Conclusions:

  • Cardiovascular risk and dementia neuroimaging markers are interconnected across racial/ethnic groups.
  • Women of color may benefit from cardiovascular risk reduction to mitigate small vessel disease and tau deposition.