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Summary

This summary is machine-generated.

An active lifestyle, including physical fitness and mental activities, promotes brain health and cognitive resilience in older adults. Genetic risk for Alzheimer's disease may accelerate brain aging, even in healthy individuals.

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Area of Science:

Neuroscience
Gerontology
Public Health

Background:

Aging is associated with cognitive decline, but individual differences in resilience and pathology resistance are significant.
A multimodal approach is needed to understand the interplay of lifestyle, health, and brain aging.
Alzheimer's disease (AD) genetic risk and biomarkers offer insights into pathological aging processes.

Purpose of the Study:

To characterize latent structures of lifestyle, mental, and physical health in older adults.
To estimate indices of brain and cognitive aging, including pathological markers.
To investigate the relationship between lifestyle/health profiles, AD genetic risk, and brain/cognitive aging.

Main Methods:

Analysis of 211 cognitively normal older adults (≥60 years) using principal component analysis (PCA) on 30 lifestyle/health variables.
Calculation of Brain Age Gap (BAG) and Cognitive Age Gap (CAG) incorporating AD pathology, white matter hyperintensities, and enlarged perivascular spaces.
Regression analysis of lifestyle/health principal components (PCs) on BAG and CAG, and t-tests for APOE e4 carriers.

Main Results:

Active lifestyle (PC2) was associated with both lower Brain Age Gap (BAG) and Cognitive Age Gap (CAG).
Mental leisure activities showed associations with Cognitive Age Gap (CAG), independent of brain pathology.
APOE e4 carriers exhibited a significantly higher BAG, indicating accelerated brain aging.

Conclusions:

An active lifestyle encompassing physical fitness and mental engagement promotes cognitive resilience and brain maintenance.
Mental leisure activities may confer cognitive resilience independently of underlying brain pathology.
Genetic predisposition to Alzheimer's disease can accelerate brain aging in cognitively healthy older adults.