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Alzheimer's Imaging Consortium.

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Summary
This summary is machine-generated.

Positron Emission Tomography (PET) imaging reveals how tau pathology impacts cognition in early Alzheimer's disease (AD). Specific cognitive domains show distinct associations with tau tangle distribution across the brain.

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Posdinemab, an anti-phosphorylated tau antibody, is studied in early Alzheimer's disease (AD).
  • The Auτonomy trial (NCT04619420) included participants with mild cognitive impairment or dementia and intermediate tau levels.
  • Tau levels were assessed using plasma assays and confirmed with tau Positron Emission Tomography (PET).

Purpose of the Study:

  • To analyze voxelwise associations between cognitive domains and tau PET.
  • To reconstruct a brain-wide map illustrating these associations.
  • To understand how tau pathology relates to cognitive function in early AD.

Main Methods:

  • Neurofibrillary tangle levels were quantified using 18F-MK-6240 SUVR in 422 participants.
  • SUVR volumes were aligned to standard brain space and smoothed.
  • Spearman rank correlation was used to assess associations between cognitive domains (RBANS indices) and tau PET, generating a domain preference map.

Main Results:

  • Significant correlations between tau PET and cognitive domains were observed across most of the brain.
  • Visuospatial function correlated with the right occipital cortex.
  • Language, delayed memory, attention, and immediate memory showed associations with specific brain regions, including temporal, parietal, frontal, and occipital lobes.

Conclusions:

  • This study maps the impact of tau pathology on cognitive domains in early AD using tau PET.
  • The generated maps align with known brain functional organization.
  • Findings highlight a strong association between the presence and location of tau tangles and an individual's cognitive profile.