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Summary
This summary is machine-generated.

Brain arteriolosclerosis (ARTS) onset averages 93 years, with earlier onset in women and Black/Latino individuals. Faster ARTS accumulation occurs in males and Black participants, influenced by mixed pathologies.

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Area of Science:

  • Neurology
  • Radiology
  • Gerontology

Background:

  • Brain arteriolosclerosis is a key factor in cerebral small vessel disease, impacting cognition and increasing dementia risk.
  • Currently, arteriolosclerosis diagnosis is limited to autopsy, hindering in-vivo research.
  • Previous work established an MRI-based classifier for arteriolosclerosis, known as ARTS.

Purpose of the Study:

  • To estimate the age of onset for brain arteriolosclerosis using the ARTS classifier.
  • To analyze the longitudinal progression of arteriolosclerosis.
  • To investigate factors influencing arteriolosclerosis onset and progression in individuals without dementia.

Main Methods:

  • Utilized MRI data from 1,195 dementia-free participants across five longitudinal studies.
  • Applied Gaussian Mixture Modeling (GMM) to identify high and low ARTS score groups.
  • Employed Sampled Iterative Local Approximation (SILA) to model ARTS accumulation trajectories and linear mixed-effects models to analyze influencing factors.

Main Results:

  • The mean age of arteriolosclerosis onset was estimated at 93 years.
  • Females and Black/Latino participants showed earlier onset compared to males and White participants.
  • Males, Black participants, and those with severe arteriolosclerosis or other pathologies exhibited faster ARTS accumulation.

Conclusions:

  • Brain arteriolosclerosis onset and progression vary significantly by sex and race/ethnicity.
  • Mixed pathologies, including atherosclerosis and infarcts, accelerate arteriolosclerosis accumulation.
  • Findings provide crucial insights into the in-vivo progression of cerebral small vessel disease.