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Summary
This summary is machine-generated.

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index did not differ significantly across Alzheimer's disease (AD) continuum stages. Age negatively correlated with the DTI-ALPS index, suggesting age-dependent glymphatic system dysfunction.

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Area of Science:

  • Neuroscience
  • Radiology
  • Gerontology

Background:

  • The glymphatic system clears waste from the brain and is implicated in Alzheimer's disease (AD) pathophysiology.
  • Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a novel method for assessing glymphatic function.
  • Investigating glymphatic system changes across the AD continuum is crucial for understanding disease progression.

Purpose of the Study:

  • To evaluate differences in the DTI-ALPS index across the Alzheimer's disease (AD) continuum.
  • To explore the relationship between the ALPS index and clinico-demographic factors, including age.

Main Methods:

  • Cross-sectional study at Keio University Hospital involving healthy controls (HC), mild cognitive impairment due to AD (MCI-AD), and dementia due to AD (D-AD).
  • Amyloid-beta positivity confirmed in MCI-AD and D-AD groups using 18F-florbetaben PET.
  • DTI data acquired with 3T MRI; ALPS index calculated from diffusion tensor of association and projection fibers.
  • Analysis of covariance (ANCOVA) used to compare ALPS index across groups, adjusting for age.

Main Results:

  • Cohort included 48 HC, 38 MCI-AD, and 47 D-AD participants.
  • A significant negative correlation was found between the ALPS index and age (r=-0.40, p < 0.01).
  • No significant differences in the ALPS index were observed among HC, MCI-AD, and D-AD groups after adjusting for age (p = 0.80).

Conclusions:

  • Age-dependent dysfunction of the glymphatic system is supported by the negative correlation between age and the ALPS index.
  • Unlike previous studies, no significant differences in ALPS index were found across the AD continuum in this cohort.
  • The DTI-ALPS method may have limited sensitivity in detecting early-stage glymphatic dysfunction in the AD continuum, warranting further research.