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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Brain Imaging01:14

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
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Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Related Experiment Video

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

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Alzheimer's Imaging Consortium.

Joshua L Gills1, Hubert Leo2, Omonigho M Bubu1

  • 1NYU Grossman School of Medicine, New York, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Certain proteins linked to synaptic vesicle exocytosis and inflammation show associations with cognitive function and dementia risk in older adults. Further research with larger sample sizes is needed to confirm these findings.

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Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Gerontology

Background:

  • Neurodegenerative diseases like Alzheimer's disease (AD) cause progressive cognitive decline.
  • Plasma biomarkers are crucial for early detection and risk assessment of AD.
  • High-sensitivity assays like NULISA™ can measure low-abundance AD-associated proteins.

Purpose of the Study:

  • To examine associations between NULISA™-quantified plasma biomarkers and cognitive performance.
  • To investigate the predictive value of these biomarkers for incident dementia in older adults.

Main Methods:

  • Utilized data from 116 ARIC cohort participants.
  • Quantified plasma biomarkers using the NULISA™ CNS 126 protein platform, including Aβ, p-tau, NfL, and GFAP.
  • Assessed cognitive performance and identified incident dementia cases, using regression models adjusted for covariates.

Main Results:

  • Growth differentiation factor 15 was the only protein associated with incident dementia (β = 4.7, p < 0.001).
  • Antigen CD63 (β = -0.43, p < 0.001) and Eotaxin CCL11 (β = -0.37, p < 0.001) were associated with global cognition.
  • Growth Regulated Alpha Protein CXCL1 was associated with executive function (β = -0.33, p < 0.001).

Conclusions:

  • Proteins involved in synaptic vesicle exocytosis and inflammation are linked to cognition and dementia risk.
  • The study's power was limited, necessitating larger sample sizes for broader proteomic pathway identification.
  • Future research should focus on larger cohorts to uncover novel proteomic pathways related to cognitive decline and dementia.