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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Related Experiment Video

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

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Alzheimer's Imaging Consortium.

Rufeyda Yagci1, Tatjana Schmidt2, Marcella Montagnese2

  • 1Istanbul Medipol University, Istanbul, Istanbul, Turkey.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Diffusion Tensor Imaging (DTI) reveals significant white matter changes in Alzheimer's disease (AD) patients, supporting its use in clinical diagnosis. These microstructural alterations in key brain regions highlight disruptions in memory and executive functions.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Diagnostics

Background:

  • White matter (WM) degeneration is an early indicator of Alzheimer's disease (AD).
  • Alterations in WM integrity, including fractional anisotropy (FA) and mean diffusivity (MD), may reflect AD pathology.
  • Diffusion Tensor Imaging (DTI) offers a method to investigate these microstructural changes.

Purpose of the Study:

  • To investigate microstructural changes in white matter of Alzheimer's disease patients using DTI.
  • To assess the applicability of DTI measures in a real-world clinical setting for AD diagnosis.

Main Methods:

  • 30 AD patients and 42 controls underwent Diffusion-Weighted Imaging (DWI).
  • Data were preprocessed using Micapipe to derive FA and MD values.
  • 25 regions of interest (ROIs) were analyzed using FMRIB Software Library (FSL) tools.

Main Results:

  • Significant differences in FA and MD were observed between AD patients and controls across multiple ROIs.
  • After normalization using reference tracts, 6 regions showed significant FA differences and 18 showed significant MD differences.
  • Key affected areas included the hippocampus, fornix, and cingulate gyrus.

Conclusions:

  • DTI measures show potential as diagnostic tools for Alzheimer's disease evaluation in routine clinical practice.
  • Observed white matter changes in limbic system structures and pathways support disruptions in memory, executive processing, and inter-hemispheric communication in AD.
  • Findings provide a basis for further research into DTI's diagnostic application for AD pathology.