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Published on: August 22, 2012
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Public Health.
Diandra N Denier-Fields1, Maisha Islam1, Nathaniel A Chin1
1University of Wisconsin-Madison, Madison, WI, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Improving cardiovascular health through the American Heart Association's Life's Essential Eight (LE8) may lower Alzheimer's disease (AD) biomarkers like ptau217 and GFAP. This suggests lifestyle factors play a role in dementia risk.
Area of Science:
- Cardiovascular Health
- Neurology
- Biomarker Research
Background:
- The American Heart Association (AHA) Life's Essential Eight (LE8) assesses cardiovascular health via eight lifestyle factors.
- Poor cardiovascular health is linked to cognitive decline and dementia.
- Blood-based biomarkers are emerging tools for assessing dementia risk, including Alzheimer's disease (AD).
Purpose of the Study:
- To investigate the association between LE8 scores and concurrent plasma biomarkers related to AD.
- To determine if lifestyle factors measured by LE8 correlate with specific AD-related biomarkers.
Main Methods:
- 942 dementia-free participants from the Wisconsin Registry for Alzheimer's Prevention (WRAP) cohort were analyzed.
- LE8 scores were calculated and matched with plasma biomarkers (ptau217, Aβ42/40, GFAP, NfL) measured within a 6-month window.
- General linear models adjusted for age, sex, and APOE were used to evaluate associations.
Main Results:
- Higher LE8 scores (indicating better cardiovascular health) were significantly associated with lower concentrations of ptau217 and GFAP.
- Each point increase in LE8 score correlated with decreased ptau217 and GFAP levels.
- No significant associations were found between LE8 scores and Aβ42/40 or NfL.
Conclusions:
- Better cardiovascular health, as defined by LE8, may be linked to reduced levels of certain AD-related plasma biomarkers.
- Further longitudinal research is required to confirm these associations and their impact on cognitive decline and brain changes.
- These findings highlight the potential role of lifestyle interventions in dementia prevention strategies.
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