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Related Concept Videos

Primary Healthcare Services01:30

Primary Healthcare Services

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Levels of Health Promotion and Illness Prevention01:26

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Healthcare Agencies II01:17

Healthcare Agencies II

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There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
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Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
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Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

William J Canestro1, Mark Monane2, Randall J Bateman3

  • 1University of Washington Institute for Protein Design, Seattle, WA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

The PrecivityAD2 blood test offers a cost-effective alternative for Alzheimer's disease diagnosis, significantly reducing healthcare costs compared to traditional PET or CSF biomarkers. This approach maintains high diagnostic accuracy while lowering the financial burden on patients and payers.

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Area of Science:

  • Neurology
  • Biomarker Discovery
  • Health Economics

Background:

  • Blood biomarkers (BBMs) are emerging as accessible alternatives to PET or CSF for Alzheimer's disease (AD) diagnosis.
  • The PrecivityAD2 test, a multi-analyte assay, demonstrates high accuracy in detecting brain amyloid plaques.
  • While clinically validated, the budgetary impact of PrecivityAD2 has not been extensively studied.

Purpose of the Study:

  • To evaluate the budget impact of adopting the PrecivityAD2 test as an early diagnostic tool for Alzheimer's disease.
  • To compare the cost-effectiveness of PrecivityAD2 against current standard-of-care biomarker testing (PET/CSF).

Main Methods:

  • A budget impact model was developed for a 1 million US health plan population.
  • The model simulated the adoption of PrecivityAD2 versus traditional PET/CSF testing in patients with cognitive impairment.
  • Real-world adoption, adherence, and dropout rates were incorporated to reflect clinical practice.

Main Results:

  • Early use of PrecivityAD2 showed improved sensitivity (90.1%) and reduced specificity (92.3% vs. 84.8%) compared to PET/CSF.
  • The PrecivityAD2 pathway resulted in net savings of $10.9 million ($0.91 PMPM) for a 1 million population, a 26.2% cost reduction.
  • Cost savings per diagnosed case ranged from $2,753 to $3,578, driven by decreased PET/CSF utilization.

Conclusions:

  • The PrecivityAD2 test, when used early, offers significant cost savings in Alzheimer's disease diagnostic workups.
  • Adoption of PrecivityAD2 reduces the economic burden on patients and healthcare payers.
  • This blood biomarker approach maintains a high quality of care while improving diagnostic efficiency.