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Alzheimer's Imaging Consortium.

Yara Yakoub1,2, Ting Qiu1,2, Sylvia Villeneuve2,3

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|December 23, 2025
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Summary
This summary is machine-generated.

The rate of change in plasma phosphorylated tau 217 (p-tau217) is the strongest predictor of future amyloid-beta positron emission tomography (Aβ-PET) positivity in individuals at risk for Alzheimer's disease. This finding highlights the importance of longitudinal biomarker monitoring.

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Area of Science:

  • Neurology
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Plasma biomarkers like p-tau217 correlate strongly with amyloid-beta positron emission tomography (Aβ-PET) load.
  • Longitudinal assessment of these biomarkers is crucial for clinical application and trial evaluation.

Purpose of the Study:

  • To evaluate longitudinal changes in plasma biomarkers.
  • To assess associations between these changes and subsequent Aβ-PET status.

Main Methods:

  • Utilized data from 386 participants in the ADNI FNIH consortium over 11 years.
  • Analyzed longitudinal trajectories of 5 p-tau217 and 4 Aβ42/40 assays with multiple Aβ-PET scans.
  • Employed Cox proportional-hazard models to link baseline and longitudinal biomarker data to Aβ-PET positivity progression.

Main Results:

  • Plasma p-tau217 assays, unlike Aβ42/40 assays, showed increases over time in both Aβ-PET negative and positive groups.
  • Higher rate of change in plasma p-tau217 was associated with increased risk of progression to Aβ-PET positivity in Aβ-negative individuals.
  • Rate of change in p-tau217 was a stronger predictor of future Aβ-PET positivity than baseline levels.

Conclusions:

  • Plasma p-tau217 levels demonstrate longitudinal changes, while Aβ42/40 assays do not.
  • The rate of change in plasma p-tau217 is the most potent predictor of future Aβ-PET positivity among individuals initially Aβ-negative.