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This summary is machine-generated.

Aging shortens intrinsic neural timescale (INT), the brain

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Aging Research

Background:

  • Intrinsic neural timescale (INT) reflects neural activity persistence, crucial for brain function.
  • Previous studies show mixed results on INT changes with aging and Alzheimer's disease.
  • Cerebro- and cardiovascular factors may confound age-related differences in BOLD fMRI signals.

Purpose of the Study:

  • To test if INT varies with age in middle-aged and older adults.
  • To investigate how adjusting for vascular factors impacts age-related INT differences.

Main Methods:

  • Analyzed whole-brain BOLD fMRI data from 693 cognitively normal adults (Human Connectome Project-Aging).
  • Estimated INT by temporal autocorrelation decay of BOLD fMRI signal.
  • Quantified resting-state fluctuation amplitude (RSFA) to normalize for vascular factors; examined age-INT associations with and without RSFA.

Main Results:

  • Confirmed longer INT in heteromodal association and visual cortex.
  • Found shorter INT with advancing age in widespread heteromodal and limbic cortical areas.
  • Accounting for vascular factors (RSFA) weakened and reduced the spatial extent of age-related INT differences, primarily affecting the insula and mid-cingulate cortex.

Conclusions:

  • Adjusting BOLD fMRI signals for vascular contributions is critical for accurately assessing age differences in INT.
  • Future research should use direct measures of cerebrovascular reactivity and cardiovascular health to validate these findings.