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Related Concept Videos

Primary Healthcare Services01:30

Primary Healthcare Services

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Levels of Health Promotion and Illness Prevention01:26

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Healthcare Agencies II01:17

Healthcare Agencies II

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There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
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Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
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Public Health.

Kelley M Faber1, Cory Weinfeld2, Abigail Erickson3

  • 1National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indianapolis, IN, USA.

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Summary
This summary is machine-generated.

The National Institute on Aging Alzheimer's Disease Family Based Study (NIA-AD FBS) is the largest worldwide collection of familial Alzheimer's Disease, providing invaluable data and biosamples for genetic research. Over 140 publications have utilized this resource, advancing the understanding of Alzheimer's genetics.

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Area of Science:

  • Genetics
  • Neuroscience
  • Biomedical Research

Background:

  • The National Institute on Aging Alzheimer's Disease Family Based Study (NIA-AD FBS) was established in 2002 as a multi-site, longitudinal initiative.
  • Its primary goal is to serve as a comprehensive data and biosample resource for global investigators.
  • The study aims to foster collaboration and resource sharing among researchers in the field of Alzheimer's disease.

Purpose of the Study:

  • To recruit families with a high prevalence of Alzheimer's disease (AD), including those with late-onset (LOAD) and early-onset (EOAD).
  • To collect extensive clinical, genetic, and biological data from participants for research purposes.
  • To facilitate genetic studies investigating the underlying causes of familial Alzheimer's disease.

Main Methods:

  • Recruitment of families with at least two affected individuals and a willing first-degree relative.
  • Collection of diverse biosamples including DNA, plasma, and PBMCs, alongside clinical and cognitive data.
  • Uniform assessments across multiple sites, with options for in-person or remote evaluations and mobile phlebotomy services.

Main Results:

  • Recruited 1,756 families, comprising 9,682 family members from Caucasian, African American, and Hispanic ethnic groups.
  • Assembled a rich dataset including longitudinal clinical data, cognitive assessments, family history, and various biosamples.
  • Generated genotype data encompassing APOE, GWAS, WES, WGS, brain methylation, RNA sequencing, and biomarker data.

Conclusions:

  • The NIA-AD FBS represents the world's largest cohort for familial Alzheimer's disease research.
  • Data and samples from this study have been instrumental in over 140 publications on Alzheimer's genetics.
  • The comprehensive resources provided by the NIA-AD FBS are crucial for advancing scientific understanding of Alzheimer's disease.