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Related Experiment Video

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Amir Abbas Tahami Monfared1, Raymond Zhang2, Quanwu Zhang3

  • 1Alzheimer's Disease & Brain Health, Eisai Inc., Nutley, NJ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary

Lecanemab adoption in early Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients shows varied uptake. Characteristics of patients receiving lecanemab infusions reveal differences in demographics and comorbidities compared to non-recipients.

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Area of Science:

  • Neurology
  • Pharmacology
  • Health Services Research

Background:

  • Lecanemab, a treatment for early Alzheimer's disease (AD), has been available in the US since January 2023.
  • This study examines patient characteristics and geographic distribution of lecanemab infusions among Medicare beneficiaries with mild cognitive impairment (MCI) or AD.

Purpose of the Study:

  • To understand the patient profile receiving lecanemab.
  • To analyze geographic variations in lecanemab infusion rates.
  • To compare demographics and comorbidities between lecanemab recipients and non-recipients.

Main Methods:

  • Utilized Medicare fee-for-service "preview claims" data from January to September 2024.
  • Identified lecanemab infusions using HCPCS code J0174.
  • Compared patient demographics, comorbidities, and urban/rural residence between infusion and non-infusion groups.

Main Results:

  • The 2,512 patients receiving lecanemab were younger (mean age 75.4) and had fewer comorbidities than non-recipients (mean age 80.8).
  • The lecanemab group was predominantly White (91.1%) and resided in urban areas (88.7%).
  • Higher infusion rates were observed in states like Connecticut and Kentucky (1.9%).

Conclusions:

  • Lecanemab adoption is likely higher than the observed 1% rate in 10 states, considering the denominator included unconfirmed cases and later disease stages.
  • Increased adoption is anticipated with further medical education and improved delivery options, including home infusion and self-injection.
  • Focus on minority groups is crucial for equitable lecanemab uptake.